8/22/2023 0 Comments Biff chip and kipper games![]() Read with Biff, Chip, and Kipper Flashcards: Word Games Synopsis LoveReading4Kids Find This Book In Suitable For: Finally, there are two sets of Flashcards – Word Games and Alphabet Games with further sets coming in Autumn 2011. Each of the 6 levels matches the Oxford Reading Tree stages that your children will be reading at school. In both strands you’ll also find hints and tips for parents and plenty of puzzles and activities to make reading fun for kids. In First Stories you’ll find fun and motivating stories which introduce new readers to common words and everyday language. In the Phonics strand you’ll find enjoyable and entertaining stories which enable children to practise their letters and sounds just as they do at school. Getting ready to read (Level 1), Starting to read (Level 2), Becoming a reader (Level 3), Developing as a reader (Level 4), Building confidence in reading (Level 5) and Reading with confidence (Level 6). There are two key strands to the series – Phonics and First Stories, each of which is divided into 6 levels. The series is designed to help parents support their child’s development as a reader at home whilst complimenting what the child is learning at school with the familiar characters of Biff, Chip, Kipper and Floppy the dog. This new series called Read with Biff, Chip and Kipper has been created out of Oxford’s Read at Home series, the UK’s bestselling home reading series and has been fully revised in line with new educational guidelines. The result will be a child who loves to read. The ‘Read with Biff, Chip and Kipper’ series helps children at home to learn to read through fun, motivating stories, a clear structure and dual-track phonics and high-frequency word strands. Includes 4 advice cards with practical advice for parents on how to use the Flashcards and games to support memory and sentence making, through familiar games like snap. A Summer of Adventure - 50 Books to Inspire!įlashcards: Young children learn best when they are having fun and word playing cards can be an enjoyable way to learn to recognise a range of common words.LGBTQI+ Children's Books celebrating Pride in London and Pride Month this June.Children's Books that feature Young Carers for Carers Week 2023. ![]() Create powerful poems to cheer your friends and family - Get Creative activities inspired by Sophie Cameron’s Away with Words.Brilliant Children's Books to Read this Summer.Back to the (Book of) the Future - the exciting re-issue of a much-loved classic.30 Children's Books to Celebrate World Music Day.LoveReading wins the Small Business x Sage pop-up shop competition!.Refugees - 40 children's books to raise awareness for Refugee Week 19-25 June.10 Books for Children to Celebrate the Windrush Generation.Children's Books that celebrate brilliant teachers for National Thank a Teacher Day!.Historic win as Yoto Carnegie Medal for Writing awarded to a book in translation for the first time. ![]()
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![]() ![]() Add dry ingredients in 2 batches, beating on low after each addition and scraping down sides of bowl if necessary, until fully incorporated, about 20 seconds per batch. Add banana mixture and beat until just combined, about 30 seconds. Add eggs one at a time and beat on medium speed until fully combined, about 1 minute each. Using an electric mixer, beat butter and brown sugar on medium speed in another large bowl until light and fluffy, about 3½ minutes. Sift together flour, baking powder, baking soda, and salt in a large bowl. Step 2Ĭombine mashed banana, sour cream, and vanilla in a medium bowl. Grease a 9x5-inch loaf pan with butter and dust with flour, tapping out any excess. To ensure your homemade banana bread easily pops out of the pan, line the pan with parchment paper: Brush melted butter (or use cooking spray) on the pan to anchor the parchment, secure it with binder clips, then grease and flour the pan as indicated below. Interested in peanut butter banana bread? A pumpkin bread modification? Or recipes made with cream cheese or whole wheat flour? You’ll find those and more in the variations section of this other recipe. If you swing the other way, add ½ cup chopped semisweet chocolate (or chips) along with or instead of the nuts. Into chocolate chip banana bread? Our testers were divided, but ultimately determined that chocolate masked the delicate banana flavor more than we liked. Or, if you prefer pecans, add those to your mixing bowl instead. If you’re a nut-free household, leave them out. This is an easy recipe with minimal prep time, so you can go from looking for the best banana bread recipe to eating exceptional banana bread in under 2 hours.Ī note about mix-ins: We like banana bread with walnuts, which add a warm, toasty, crunchy textural contrast. Then we combined the things we liked about other quick breads into the ideal breakfast loaf: a sweet, nutty, and supremely moist banana bread with a delicate crumb. To create our ultimate banana bread recipe, the Epi test kitchen team baked the most popular versions in our archives to determine what made each one so delicious. ![]() 8/22/2023 0 Comments Ben fink 17502![]() Degradation by the 26S proteasome, which is composed of the 19S and 20S particles, is an active process that is regulated by a series of enzymes that ubiquitinate the substrate and sensitize it to degradation 21. This class of proteins can be degraded by two alternative proteasomal degradation mechanisms, which are not mutually exclusive: ubiquitin-dependent degradation by the 26S proteasome and ubiquitin-independent degradation by the 20S proteasome. In general, substrates of the 20S proteasome are composed of proteins containing unstructured or relatively unfolded regions 20. Our results revealed that DJ-1 is a regulator of the ubiquitin-independent 20S proteasomal degradation pathway. Here we combined biochemical and native mass spectrometry approaches, together with cell biology methods, to study the molecular function of DJ-1. Overall, despite the broad interest and impressive progress that has been made in DJ-1 characterization, its key biological functions, and direct and indirect biological implications, remain unclear. ![]() DJ-1 was also shown to upregulate glutathione synthesis and heat shock proteins 16, alter dopamine receptor signalling 17 and coordinate p53 signalling 18, 19. These include roles as a cysteine protease 10, redox-regulated chaperone 11 and transcription modulator 12, as well as involvement in anti-apoptotic signalling processes 13, 14 and RNA regulation 15. To date, the molecular function of DJ-1 is still not clear, though a range of biochemical and cellular activities have been proposed for it. In addition, oxidative stress was found to induce the rapid relocalization of DJ-1 to mitochondria 7, 9, suggesting that mitochondria could be a site for DJ-1’s neuroprotective activity. This oxidative modification is thought to enable DJ-1 to act as a sensor of cellular redox homeostasis, and to participate in cytoprotective signalling pathways in the cell. Under oxidative stress, a conserved cysteine residue in DJ-1 (Cys106) is oxidized into cysteine sulfinate and cysteine sulfonate 2. It was shown to protect cells from reactive oxygen species, reduce protein misfolding and stabilize mitochondrial potential and morphology. Models of DJ-1 deficiency or overexpression have provided evidence that the protein takes part in the oxidative stress response 7, 8. The specific role of the protein in the pathogenesis of PD is still unclear however, the diversity of disease states in which DJ-1 is implicated suggests its involvement in a fundamental biological process. A decade ago, it was realized that missense, truncation and splice site mutations in DJ-1 all lead to an autosomal recessive, early-onset familial form of Parkinson’s disease (PD reviewed in refs 2, 6). DJ-1 was also implicated in additional disorders such as ischaemic injury, amyotrophic lateral sclerosis 4, 5, fertility control and androgen receptor regulation 2. DJ-1 was originally identified as an oncogene and its expression was found to be upregulated in several malignancies including breast, lung and prostate cancer. Belonging to the ThiJ/PfpI protein superfamily, DJ-1 is highly conserved, with homologues distributed across all biological kingdoms 3. Such a tight regulation of the 20S proteasome may sustain the balance between the need to rapidly eliminate oxidatively damaged proteins and maintain the abundance of native, intrinsically unstructured proteins, which coordinate regulatory and signalling events.ĭJ-1 is a small protein of 189 amino acids that is ubiquitously expressed in almost all cells and tissues, including the brain, and exists as a homodimer that is localized to the cytoplasm, mitochondria and nucleus (for reviews, see refs 1, 2). Overall, our results suggest a regulatory circuit in which DJ-1, under conditions of oxidative stress, both upregulates and inhibits the 20S proteasome, providing a rigorous control mechanism at a time when the 20S proteasome becomes the major proteolytic machinery. Furthermore, we demonstrate that following oxidative stress, DJ-1 is involved in the Nrf2-dependent oxidative stress response that leads to the upregulation of both the 20S proteasome and its regulator, NQO1. Consequently, DJ-1 stabilizes the cellular levels of 20S proteasome substrates, as we show for α-synuclein and p53. We show that DJ-1 physically binds the 20S proteasome and inhibits its activity, rescuing partially unfolded proteins from degradation. ![]() Here we demonstrate that DJ-1 is a 20S proteasome regulator. ![]() The Parkinson’s-associated protein, DJ-1, is a highly conserved homodimer, ubiquitously expressed in cells. ![]() 8/22/2023 0 Comments Login turbotax account number![]() ![]() TurboTax® and Quicken® are registered trademarks of Intuit, Inc. H&R Block is a registered trademark of HRB Innovations, Inc.Terms and conditions apply see Accurate Calculations Guarantee for details. If the online tax preparation or tax software makes an arithmetic error that results in your payment of a penalty and/or interest to the IRS that you would otherwise not have been required to pay, H&R Block will reimburse you up to a maximum of $10,000.To qualify for the H&R Block Maximum Refund Guarantee, the refund claim must be made during the calendar year in which the return was prepared and the larger refund or smaller tax liability must not be due to incomplete, inaccurate, or inconsistent information supplied by you, positions taken by you, your choice not to claim a deduction or credit, conflicting tax laws, or changes in tax laws after January 1, 2023. If you discover an error in the H&R Block tax preparation software that entitles you to a larger refund (or smaller liability), we will refund the software fees you paid to prepare that return and you may use our software to amend your return at no additional charge.Federal pricing will vary based upon individual taxpayer circumstances and is finalized at the time of filing. Additional fees apply for tax expert support.Additional terms and restrictions apply See Guarantees for complete details. It does not provide for reimbursement of any taxes, penalties, or interest imposed by taxing authorities and does not include legal representation. Free Worry-Free Audit Support is available only for clients who purchase and use H&R Block desktop software solutions to prepare and successfully file their 2022 individual income tax return (federal or state).If you want to change your bank account or routing number for a tax refund, call the IRS at 80. If the bank returns your direct deposit, the IRS will send a paper check to the mailing address listed on your return. If you don’t contact the IRS, they’ll first try to send your refund to the bank account and routing number listed in the return. You can only request that the IRS issue you a check – and that’s only if the return has not yet been processed. ![]() If the IRS has accepted your return already, you won’t be able to change your bank and routing number for your tax refund. If you’ve already filed your return, you can review your direct deposit information on a copy of your return. Re-enter the same information to confirm. When prompted, enter your routing number and account number. Go to the File section of the H&R Block Online product.If you haven’t yet filed your return, or if the IRS rejected your return: However, the process is different depending on whether or not you’ve successfully filed your return. If necessary, you can change a wrong bank account and routing number for a tax refund. Steps to Change Your Bank Account and Routing Number for Your Tax Refund Do you need to change your banking and routing numbers for your tax refund from your checking account to your savings account, or vice versa? If so, we can walk you through the process. ![]() 8/22/2023 0 Comments Light purple iphone wallpaper![]() ![]() Some people think that its an art of wallpapers others think it’s a style, but for me this is a about my system or pc, in simple way with beautify the modern technology. ![]() Get the most amazing Aesthetic Purple Computer Wallpaper that make your pc background more attractive and stylish. All of the images here have been selected to ensure that they are high-quality pictures with large resolution so that they will fit nicely as wallpaper Pastel Aesthetic Purple Wallpaper ultra hd Purple Fantasy Wallpaper To set these as background, just click on a picture you want and right click then choose ‘save image as’. Pastel Aesthetic Purple Wallpaper, These are very suitable as wallpaper for your desktop and mobile phones. Aesthetic Purple Wallpaper Anime cute, girl anime images hd pictures Cute Aesthetic Purple Wallpaper Anime are here for free download. The mixture he made with burned coal created a rich purple called mauveine. It has been around as a color for as long as human history, but was only made the official color of the dye in 1862 by an English chemist named William Henry Perkin. Purple is a color that comes from mixing blue and red. All Types Of Purple Hd WallpapersĬute Hd Aesthetic Purple Wallpaper Cat Bright light wallpaper You may click here to get latest and fully detailed information about List of Aesthetic Purple Wallpapers. We know there are many purple lovers in the world and they want to use purple color wallpapers for their iPhones. We are sharing different colored purple wallpapers for your iPhones. There are many different shades of purple color and different people like different shades. We are sharing some amazing and interesting Purple Wallpapers For iPhone Background. We are moving towards our next topic which is Purple Wallpapers For iPhone Background. So, now that we have shared some information about the purple color. Purple is the favorite color of many people across the world. When combined with pink, it is associated with eroticism femininity and seduction. According to contemporary surveys in Europe and the United States, purple is the color most often associated with rarity, royalty, magic, mystery, and piety. Similarly, in Japan, color is traditionally associated with the emperor and aristocracy. Purple was the color worn by Roman magistrates it became the imperial color worn by the rulers of the Byzantine Empire and the Holy Royal Empire and later by Roman Catholic bishops. Purple has long been associated with royalty, originally because the Tyrian purple dye made from crushed shells, was extremely expensive in antiquity. Blue-dominated hues may be classed as violet instead, especially in the United Kingdom. These are the images directly from iOS, so they should look great on your devices.Purple Wallpapers For iPhone Background | Dark light Purple HD Images For iPhone: Purple is basically a color with a hue between red and blue. (Depending on your device, you might need to open the images in a new tab to download full-resolution images. Long press again to ‘Save’ on iOS or ‘Save image as’ on macOS.Right-click or long-press on the image you want to choose below and open in a new tab.When set through iOS 15, these are live wallpapers that animate when you press on them, but unfortunately there is no easy way for us to share the live mode versions right now. There are also light mode and dark mode variants of each of the wallpapers. The iPhone 13 mini and iPhone 13 wallpapers match the new colors of the iPhone 13 lineup: red, midnight, starlight, blue, and pink. The wallpapers are available in four different variations - dark gray, gold, silver, and blue - to match the graphite, gold, silver, and sierra blue color options for the new iPhone 13 Pro and iPhone 13 Pro Max. The new iPhone 13 Pro and iPhone 13 Pro Max wallpapers match the colors of the new iPhones themselves. We’ve extracted the new wallpapers directly from the iPhone 13 and iPhone 13 Pro builds of iOS 15 released today, so you can download them for your iPhone model below. Like every year, the new iPhone 13 and iPhone 13 Pro include a new collection of slick wallpapers for you to use. ![]() 8/22/2023 0 Comments Tucson expo center capacity![]() ![]() Only minutes from Downtown Tucson with multitudes of hotel rooms and shopping in close proximity, local and regional guests alike can easily access our expansive facility for all types of events. Questions about the Tucson Real Estate Market or Tucson Homes for Sale? Call Us - 5 OR complete the - CONTACT FORM - and we will get right back to you!The Tucson Expo Center is Tucson's premier multi-purpose facility, conveniently located off the I-10 minutes away from the Tucson International Airport. And get regular updates on the Real Estate Market and events in Tucson, AZ. Sign UP to receive daily HOME TRACKER UPDATES - OR - Our Monthly NEWSLETTER. The recent opening of the new streetcar system provides better access to downtown restaurants, shops and University of Arizona.The Tucson Convention Center project will add to the many reasons for residents and visitors to “come on down” to downtown Tucson.Ĭonsidering a move to Tucson Arizona OR looking for a future place to call home? We can help! The downtown areas in the City of Tucson are continuing to be revitalized. A grand opening event is slated for January 2015. The additional work will provide a new entrance and east side ticket office signage. The rest of the project is scheduled to be completed by the end of 2014. While almost completed, there is another 20% to be done to finish the arena renovations. Members of Tucson’s media previewed the renovated Tucson Convention Center area on Thursday, October 9, 2014. Those attending the upcoming (October 11, 2014) performance of Disney on Ice this weekend at the Tucson Convention Center will be the first public group to experience the transformation. TCC Arena: 4,988 permanent seats, 2,724 bleacher seats, and floor capacity for 888.Leo Rich Theater: 511 seats- for small scale and more intimate performances.TCC Music Hall: seats 2,289 seats- used for concert performances, including opera.Performance Venues at the Tucson Convention Center, include: SMG will management the facilities of the Tucson Convention Center as well as use their network of clients, booking services and resources to improve the economic performance of SMG is a recognized municipal facilities management company with over 230 facilities under management worldwide. They will manage operations of the Tucson Convention Center, Tucson Arena, Tucson Music Hall and Tucson Leo Rich Theater. In conjunction with the renovation, the City of Tucson has entered into a management agreement with SMG on October 1, 2014. Funding was provided by Rio Nuevo and the City of Tucson. The $8.8 million project will renovate seating, concession stands, sound system, lighting and video display. Rio Nuevo began remodeling TCC in March 2014. The TCC is a focal point of the Rio Nuevo District. ![]() Now, after years of planning, new life is coming to the Tucson Convention Center. Unfortunately, after 40+ years, the facility became outdated and run down. Perhaps the biggest is the annual Tucson Gem and Mineral Show based at TCC. TCC has been home to many Tucson events during the over 40 years since it opened. When it opened, TCC provided over 200,000 square feet of meeting and exhibition space combined with a 500+ seat theater, 2200+ music hall and 8900 seat arena.įor the historians, the Tucson Convention Center was originally identified as the Tucson Community Center. ![]() The Tucson Convention Center is the largest multiple venue facility in southern Arizona. ![]() The Tucson Convention Center Renovation Is Scheduled For Completion December 2014 Tucson Convention Center Renovation Update ![]() 8/22/2023 0 Comments Standing butterfly origami![]() origami butterfly- love the paper!īlue ombre butterfly heart / 3D paper art / by Flybybutterfly1 #ad origami butterfly, origami instructions and dollar bill butterfly See more. ![]() How to make a 3d origami butterfly Stumbled upon this while looking for instructions for how to make an origami butterfly. Origami Swallowtail Butterfly origami motyl krok po kroku / how to make a origami butterfly tutorial 3D. This is a fairly complex model, the scheme which may embarrass the inexperienced artists. 02:44.Įxcellent model of the great masters of origami Robert Lang. Origami animals for kids instructions Origami animals for kids 3d. Origami butterfly instructions How to make paper butterfly. 3D Origami Butterfly INSTRUCTIONS: Pictures taken from: http Cute Hello Kitty and friends made of 3D origami.How to DIY Origami Butterfly by How to make a 3d origami butterfly How to make a dainty Origami Butterfly. Origami, 3D origami frog tutorial, How to Make an Easy Origami Butterfly, How to make Paper Pyramid ( very easy ), DIY Crafts, Origami Flor Del Rio (Erny), OrigamiĪ fun activity allowing your children to create their own little paper folded butterfly!įind great deals on eBay for origami dollar bill butterfly Money Origami Sculpture Simple BUTTERFLY 3D Dollar Bill Origami – 72 page book with instructions Origami 3d Triangle Instructions In this article you can find instructions on how to create a butterfly from paper. This hands-on activity Our origami DNA instruction video. ![]() Origami Letters 3d Instructions Butterfly Activity Instructions Origami Butterfly. ![]() 8/22/2023 0 Comments Freedom health inc![]() The plans have been growing rapidly and now serve about 1 in 3 people on Medicare, or about 20 million people. Medicare Advantage plans are privately run alternatives to standard Medicare. Shots - Health News GAO Audit: Feds Failed To Rein In Medicare Advantage Overbilling "Although Medicare managed care is a complex and constantly changing industry in which it is common to have differing interpretations of regulations, with this settlement, we have agreed to resolve disputed claims without any admission of liability in order to avoid delay and the expense of litigation, so that we can focus on providing quality care, member service and maintaining the highest Medicare Star Ratings," Patel said. In a statement, Freedom and Optimum corporate counsel Bijal Patel denied any wrongdoing. She said the settlement "sends an important signal to health insurers that the government is serious about risk adjustment fraud." "This is the largest whistleblower settlement involving health insurers' manipulation of their members' risk scores," said Mary Inman, a San Francisco attorney who represented Sewell. The Sewell case is among the first to settle. ![]() At least a half-dozen whistleblowers have sued health plans alleging they tampered with the billing formula to improperly boost profits. Overspending tied to inflated risk scores has repeatedly been cited by government auditors, including the Government Accountability Office. "This settlement underscores our Office's commitment to civil health care fraud enforcement." Attorney Stephen Muldrow said in a statement. "Medicare Advantage plans play an increasingly important role in our nation's health care market," acting U.S. The payment formula, known as a risk score, has been in use since 2004. The Florida settlement comes amid growing government scrutiny of Medicare Advantage plans, which receive higher payments for sicker patients than for those in good health. Sewell alleged that Medicare overpaid the health plans after the companies made patients appear sicker than they were or claimed patients had been treated for medical conditions they either did not have or for which they had not been treated. He died in 2014, but his family took over the case. ![]() Darren Sewell, a physician and former medical director of both plans, who worked for them from 2007 to 2012. The two plans are Freedom Health and Optimum HealthCare, both based in Tampa. The suit, settled on Tuesday, alleged that two of the company's insurance plans exaggerated how sick patients were and took other steps to overbill the government health program for the elderly. A whistleblower lawsuit alleged that two Florida insurance plans inflated fees by making patients appear sicker than they were.įreedom Health Inc., a Florida Medicare Advantage insurer, has agreed to pay nearly $32 million to settle a whistleblower lawsuit. ![]() 8/22/2023 0 Comments Biloxi little theatre events![]()
8/22/2023 0 Comments Small log cabin interior![]() ![]() But when styled with the right decorative elements, they pay tribute to nature in the most modern way. The wooden walls alone from modish cabins set the warmth into place. This approach introduces the natural beauty of the outdoors into the cabin’s core. Log Cabin Decor Ideas: InteriorĮlements that incorporate a touch of Mother Nature are a log home interior ’s signature. This post will guide you through a rundown of cabin decor ideas for more inspiration tips. When it comes to the design, the focus can be more than pine furniture pieces and sheepskin rugs. If you’ve recently invested in one, you might be looking for ways to style the inside of your garden building. And to make the most of your stay, the interior needs to spice up. Instead, in the solace of your outdoor space. The catch is you get to experience this without stepping out of your property. Known for their rustic charm, they take you out of the busy city life and bring you into the calm idyll of the woods. Should you paint the inside of your log cabin?Įmbrace the rustic surroundings and touch of nature in the comfort of your garden cabin as ever!įrom the forests deep to finding their place in many home gardens, log cabins are everywhere.How do you brighten up a dark log cabin?.How do you decorate the inside of a log cabin?.How do you brighten up your log cabin interior?.Instead, choose new furniture with clean lines, and pepper in vintage pieces as accents, and a way to tie together new style and old. ![]() Vintage decor is a natural fit for cabins, but if you use only vintage, you'll run the risk of an older cabin looking like a time capsule. Even giving an old brick fireplace a coat of black or white paint can make it feel more modern. Or, in a bedroom, paint only the wall behind the bed for an accent wall idea that creates a focal point. For example, if you own a chalet-style cabin with a pitched interior roof, you can paint the walls below the roofline to preserve the wood tones while adding a modern element. There are a lot of ways to use paint for wood ceiling ideas so it adds character to your cabin. Painting interior timber beams can feel like a sacrilege, but it's not. Replace old flooring with hardwoods, or luxury vinyl plank flooring with a wood look. Old carpet or peeling linoleum will make your cabin feel dirty and dingy no matter what other updates you do. Replacing (or painting) old cabinetry, adding new fixtures, and re-tiling floors can make the entire home feel renewed. Perhaps the biggest impact you can make on an old cabin is to update the kitchen and bathrooms. But, you can achieve both the goal of having a modern cabin space without stripping away its character. So, you can't exactly give it a gut renovation. Modernizing a cabin isn't like updating any other home, because the characteristics that may make it feel dated are likely the same ones that give it its rustic charm. ![]() In this space by Stonorov Workshop Architects the simple, contemporary lines of the Duravit bathtub add just the right amount of modern contrast to this primitive bathroom. (Image credit: Stonorov Workshop Architects)Ĭabins celebrate nature, and what better vantage point from which to take in the great outdoors than a soaking tub filled to the brim with bubbles? (Especially if it follows a long day on the hiking, biking, or skiing trail). ![]() |
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